Salivary excretion of 5-fluorouracil(5-FU). III. Non-linear kinetics of salivary excretion of 5-FU following bolus intravenous administration in rats.
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چکیده
منابع مشابه
Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
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Introduction: 5-Fluorouracil (5-FU) is the basis of most combination chemotherapies for gastrointestinal tumors. It is generally well tolerated, but side-effects might require dose-adjustment. As adverse events are not specific to the 5-FU component of the chemotherapy-combination, i.e. neutropenia, diarrhea or cardiotoxicity, the knowledge of 5-FU serum levels might help to attribute these sid...
متن کاملEffect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals
Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
متن کاملMenthol towards 5-FU
Borneol and menthol were two terpenes wildly used as penetrate enhancer in 14 transdermal drug delivery. To explore their penetration enhancement effect towards hydrophilic 15 drug, 5-FU was selected as model drug. A method combined vitro permeation studies and coarse 16 grain molecular dynamics was used to investigate their penetration enhancement effect towards 17 5-FU. As a result, although ...
متن کاملincreased salivary nitrite and nitrate excretion in rats with cirrhosis
increased nitric oxide (no) formation is mechanistically linked to pathophysiology of the extrahepatic complications of cirrhosis. no is formed by either enzymatic or non-enzymatic pathways. enzymatic production is catalyzed by no synthase (nos) while entero-salivary circulation of nitrate and nitrite is linked to non-enzymatic formation of no under acidic ph in the stomach. there is no data on...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1988
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.36.4547